ASCC Research Portfolio

Tissue Repair

Group Leader
Kathy Traianedes, MSc PhD
Senior Scientist

Contact Details
Email: kathy.traianedes@stemcellcentre.edu.au

To find out more about Kathy Traianedes, MSc PhD, click here.

Lab Members

Ayan Dasvarma - Post-Doctoral Research Scientist
Michael Thomson - Research Assistant

Research Focus

Our research is focussed on the role of cell-matrix interaction of various cell types (stem cells, progenitors and differentiated cells) with the biological matrices.

Overview

The Tissue Repair laboratory of the ASCC is focussed around the interaction of cells and the extracellular matrix. Extracellular matrix contains a complex array of structural elements and information (e.g. growth factors etc) to direct the function of cells and hence result in normal tissue regeneration and remodelling.

Several attempts have been made to produce extracellular matrix biosynthetically, however in the absence of a complete knowledge of matrix design and without a complete and available array of recombinant raw materials, such attempts to date have met with limited success. Naturally occurring biological matrices serve as the template or model for the development and construction of novel matrices.

The understanding of the cell matrix interactions with this program will ultimately lead to potential therapeutics in several areas.

Selected Publications

Book Chapters

Traianedes K, Gross K, Livesey S. Chapter 5: Biomaterials. In: Baust JG, Baust JM, editors. Advances in Biopreservation. Boca Raton, FL: CRC/Taylor & Francis Group LLC; 2007. p. 107-22.

Traianedes K, Diegmann M. Chapter 6: Bone and Soft Tissue. In: National Association of Orthopaedic Nurses: Orthopaedic Operating Room Manual. Pitman NJ, USA: AJ Jannetti Inc; 2003. p. 89-110.

Mundy GR, Oyajobi B, Traianedes K, Dallas S, Chen D. Cytokines and bone remodeling. In: Marcus R, Feldman D, Kelsey J, editors. Osteoporosis. 2nd ed. San Diego: Academic Press Inc; 2000. p. 373-403.

Journal Articles

Traianedes, K, Russell JL, Edwards JT, Stubbs HA, Shanahan IR, Knaack D. Donor age and gender effects on osteoinductivity of demineralized bone matrix. J Biomed Mater Res. 2004 Jul 15;70B(1):21-9.

Oyajobi, BO, Anderson DM, Traianedes K, Williams PJ, Yoneda T, Mundy GR. Therapeutic efficacy of a soluble RANK-IgG Fc (RANK.Fc) fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy. Cancer Res. 2001; 61:2572-2578.

Ferrari SL, Traianedes K, Thorne M, Lafage-Proust MH, Genever P, Cecchini MG, et al. A role for N-cadherin in the development of the differentiated osteoblastic phenotype. J Bone Miner Res. 2000; 15:198-208.

Greenberg Z, Stoch A, Traianedes K, Teng H, Rosenblatt M, Chorev M. Covalent immobilization of recombinant human integrin on a solid support with retention of functionality. Anal Biochem. 1999; 266:153-64.

Traianedes K, Dallas MR, Garrett IR, Mundy GR, Bonewald LF. 5-lipoxygenase metabolites inhibit bone formation in vitro. Endocrinology. 1998; 139:3178-3184.

Gault A, O'Dea K, Rowley KG, McLeay T, Traianedes K. Abnormal glucose tolerance and other coronary heart disease risk factors in an isolated aboriginal community in central Australia. Diabetes Care. 1996; 19:1269-1273.

Traianedes K, Martin TJ, Findlay DM. Regulation of osteopontin expression by type I collagen in preosteoblastic UMR201 cells. Connect Tissue Res. 1996; 34:63-74.

Traianedes K, Findlay DM, Martin TJ, Gillespie MT. Modulation of the signal recognition particle 54 kDa subunit (SRP54), in rat preosteoblasts by the extracellular matrix. J Biol Chem. 1995; 270:20891-20894.

Suda N, Gillespie MT, Traianedes K, Zhou H, Ho PW, Hards DK, et al. Expression of parathyroid hormone related protein in cells of the osteoblast lineage. J Cell Physiol. 1996; 166:94-104.

Traianedes K, Ng KW, Martin TJ, Findlay DM. Cell substratum modulates responses of preosteoblasts to retinoic acid. J Cell Physiol. 1993; 157:243-252.